Research Article

Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis

Published: November 26, 2012
Genet. Mol. Res. 11 (4) : 3998-4007 DOI: https://doi.org/10.4238/2012.November.26.1
Cite this Article:
(2012). Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis. Genet. Mol. Res. 11(4): gmr2194. https://doi.org/10.4238/2012.November.26.1
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Abstract

We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529*T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529*T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.

We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529*T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529*T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529*T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer.