Research Article

RsaI polymorphism of the ERβgene in women with endometriosis

Abstract

We examined the frequency of RsaI polymorphism of the ERβgene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymor­phisms of the ERβgene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG poly­morphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P

We examined the frequency of RsaI polymorphism of the ERβgene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymor­phisms of the ERβgene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG poly­morphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P